Isoquinoline derivatives, their preparation and their use

Details Isoquinoline derivatives, their preparation and their use Isoquinoline derivatives, their preparation and their use

C - Chemistry, Metallurgy

07

D

167/226, 260/289

C07D 217/24 (2006.01) A61K 31/47 (2006.01) C07D 217/16 (2006.01)

Patent

CA 1332944

Compounds of formula I Image (I) wherein R1 is hydrogen or C1_4alkyl; R2 is hydrogen and R3 is hydrogen or C1_4alkyl, or R2 and R3 together represent an additional bond as indicated by the dotted line; R4 is hydrogen, C1_4alkyl or phenyl; R5 is methoxy or ethoxy; R6 is hydrogen, hydroxy, C1_4alkoxy, hydroxy-(C2_4alkoxy) or (C1_4alkoxy)- (C2_4alkoxy); R7 and R8 are each independently C1_4alkoxy or (C1_4alkoxy)-(C2_4alkoxy); and R9 is hydrogen or halogen in free form or pharmaceutically acceptable salt form, have pharmaceutical utility, in particular as bronchodilators, eosinophil accumulation and/or activation inhibiting agents and in the treatment or prophylactic treatment of obstructive or inflammatory airways diseases.

587599

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