C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
167/208, 260/287
C07D 215/36 (2006.01) A61K 31/395 (2006.01) C07D 215/04 (2006.01) C07D 215/26 (2006.01) C07D 217/02 (2006.01) C07D 217/22 (2006.01) C07D 401/12 (2006.01) C07D 405/00 (2006.01) C07D 405/12 (2006.01) C07D 405/14 (2006.01)
Patent
CA 2020027
Disclosed is a sulfonamide derivative represented by following formula (I) and a medicine for the treatment of asthma comprising the sulfonamide derivative as an active ingredient which exhibits bronchodilation effect: Image (I) wherein: X represents a quinoline residue represented by formula (II) or an isoquinoline residue represented by formula (III): Image (II) Image (III) R1 is a hydrogen atom, a halogen atom, a lower alkyl group or a lower alkoxy group, or the compound of formula (III); R2 is a hydrogen atom or a hydroxyl group; when X is quinoline residue (II), n is zero or 1, in which, when n is zero, R4 is an unsubstituted or substituted diazacycloalkyl group, and when n is 1, R3 is a hydrogen atom or a lower alkyl group and R4 is an unsubstituted or substituted aralkylamino group or an unsubstituted or substituted diazacycloalkyl group; when X is isoquinoline residue (III), n is 1, in which, R3 is a hydrogen atom or a lower alkyl group and R4 is a 3,4-methylenedioxyphenethylamino group, a 3,4-methyl- enedioxybenzylamino group or an unsubstituted or substituted diazacycloalkyl group, with the proviso that when R4 is an unsubstituted or substituted diazacycloalkyl group, the diazacycloalkyl group is bonded at a nitrogen atom thereof.
Kajihara Akiro
Miyoshi Shiro
Asahi Kasei Kogyo Kabushiki Kaisha
Goudreau Gage Dubuc
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