C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 453/06 (2006.01) A61K 31/439 (2006.01) A61P 3/10 (2006.01)
Patent
CA 2441838
An isoquinuclidine derivative represented by the following general formula (I): (I) [wherein A1 is methylene or carbonyl; R1 is hydrogen or methyl; R2 is -(CH2)n-A2-Ph (n is an integer of 0 to 3 and A2 is a single bond or -O-); and R3 is -COOH, -COOR4, -COSR4 (R4 is lower alkyl, unsubstituted phenyl, or phenyl substituted by a lower alkyl, lower alkoxy, hydroxyl, methoxycarbonyl, ethoxycarbonyl, or trifluoromethanesulfonamide group or by a halogen atom), etc.] or a pharmaceutically acceptable salt of the compound. Also provided is an oral remedy for diabetes, which contains the compound and has hypoglycemic activity.
L'invention concerne un dérivé d'isoquinuclidine de la formule générale (I) dans laquelle A¿1? est -(CH¿2?)¿n?-A¿2?-Ph (n étant un nombre entier compris entre 0 et 3 et A¿2? une liaison simple ou -O-); et R¿3? est -COOH, -COOR¿4?, -COSR¿4? (R¿4? étant alkyle inférieur, phényle insubstitué, ou phényle substitué par alkyle inférieur, alcoxy inférieur, hydroxyle, méthoxycarbonyle, éthoxycarbonyle, ou un groupe trifluorométhanesulfonamide, ou phényle substitué par un atome d'halogène), etc.) ou un sel pharmaceutiquement acceptable ddu composé de l'invention. L'invention concerne en outre un remède oral pour le traitement du diabète, qui contient le composé de l'invention et présente une action hypoglycémique.
Kobayashi Yoshinori
Noda Atsushi
Tomiyama Hiroshi
Kotobuki Pharmaceutical Co. Ltd.
Smart & Biggar
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