Isoserine derivatives and their use as leukotriene antagonists

Details Isoserine derivatives and their use as leukotriene antagonists Isoserine derivatives and their use as leukotriene antagonists

C - Chemistry, Metallurgy

07

D

C07D 215/14 (2006.01) A61K 31/47 (2006.01) C07D 215/12 (2006.01) C07D 215/18 (2006.01) C07D 401/12 (2006.01) C07D 405/12 (2006.01)

Patent

CA 2134565

2134565 9403431 PCTABS00030 The present invention relates to hitherto unknown compounds of formula (I); Y stands for -CH=CH-; R1 is hydrogen or halogen, preferably fluorine, chlorine or bromine; R2 is halogen, preferably fluorine, chlorine or bromine, CH3, OCH3, NO2 or CF3, and n=0-3, preferably 0, 1 or 2; A stands for an acidic group, e.g. carboxy, 1-H-tetrazolyl or a hydroxamic acid group. The present compounds are of value in the human and veterinary practice as lipoxygenase inhibitors and/or leukotriene antagonists.

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