Isothiazole derivatives useful as anticancer agents

Details Isothiazole derivatives useful as anticancer agents Isothiazole derivatives useful as anticancer agents

C - Chemistry, Metallurgy

07

D

C07D 417/12 (2006.01) A61K 31/427 (2006.01) A61K 31/4439 (2006.01) A61K 31/498 (2006.01) A61K 31/506 (2006.01) A61K 31/517 (2006.01) A61P 35/00 (2006.01)

Patent

CA 2493701

The invention relates to compounds of the formula 1 or pharmaceutically acceptable salts, prodrugs, solvates or hydrates thereof, wherein X, R1, and R2 are as defined herein. The invention also relates to pharmaceutical compositions containing the compounds of formula 1 and to methods of treating hyperproliferative disorders disorders in a mammal by administering the compounds of formula 1.

L'invention concerne des composés de formule (1) ou des sels, des promédicaments, des solvates ou des hydates de ceux-ci, acceptables au plan pharmaceutique, formule dans laquelle X, R?1¿ et R?2¿ sont tels que définis dans la description. L'invention porte également sur des compositions pharmaceutiques contenant les composés de formule 1 et sur des procédés de traitement de troubles hyperproliférants chez un mammifère, par l'administration des composés de formule (1).

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