Isothiazole derivatives useful as anticancer agents

C - Chemistry – Metallurgy – 07 – D

Patent

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Details

C07D 487/08 (2006.01) A61K 31/425 (2006.01) C07C 33/46 (2006.01) C07C 327/58 (2006.01) C07D 209/00 (2006.01) C07D 275/03 (2006.01) C07D 417/12 (2006.01) C07D 521/00 (2006.01)

Patent

CA 2333703

The present invention relates to compounds of formula (1) and to pharmaceutically acceptable salts, prodrugs and solvates thereof, wherein X1, R1, R2 and R3 are as defined herein. The invention also relates to pharmaceutical compositions containing the above compounds and to methods treating hyperproliferative disorders in mammals by administering the above compounds.

La présente invention concerne des composés correspondant à la formule (<u>1</u>), ainsi que des sels, promédicaments et solvates de ces composés, acceptables sur le plan pharmacologique. Dans cette formule, X<1>, R<1>, R<2> et R<3> possèdent les notations données dans la description. L'invention concerne également des compositions pharmaceutiques contenant les composés ci-dessus, ainsi que des méthodes de traitement de troubles hyperproliférants, chez des mammifères, consistant à administrer les composés ci-dessus.

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