Isothiazole dioxides as cxc- and cc- chemokine receptor ligands

C - Chemistry – Metallurgy – 07 – D

Patent

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C07D 417/12 (2006.01) A61K 31/427 (2006.01) A61P 29/00 (2006.01) A61P 35/00 (2006.01) C07D 275/02 (2006.01) C07D 417/14 (2006.01)

Patent

CA 2550540

Disclosed are novel compounds of the formula (IA): and the pharmaceutically acceptable salts and solvates thereof. D and E are different groups wherein one is N and the other is CR50. Examples of groups comprising Substituent A include heteroaryl, aryl, heterocycloalkyl, cycloalkyl, aryl, alkynyl, alkenyl, aminoalkyl, alkyl or amino. Examples of groups comprising Substituent B include aryl and heteroaryl. Also disclosed is a method of treating a chemokine mediated diseases, such as, cancer, angiogenisis, angiogenic ocular diseases, pulmonary diseases, multiple sclerosis, rheumatoid arthritis, osteoarthritis, stroke and cardiac reperfusion injury, pain (e.g., acute pain, acute and chronic inflammatory pain, and neuropathic pain) using a compound of formula IA.

La présente invention concerne de nouveaux composés de formule (IA), et des sels et solvates de ceux-ci, acceptables d'un point de vue pharmaceutique. D et E sont des groupes dont l'un est N et l'autre est CR?50¿. Des exemples de groupes comprenant le substituant A, comprennent hétéroaryle, aryle, hétérocycloalkyle, cycloalkyle, aryle, alcynyle, alcényle, aminoalkyle, alkyle ou amino. Des exemples de groupes comprenant le substituant B, comprennent aryle et hétéroaryle. L'invention a également pour objet un procédé pour traiter des maladies médiées par la chimiokine telles que le cancer, l'angiogenèse, les troubles oculaires angiogéniques, les maladies pulmonaires, la sclérose en plaques, l'arthrite rhumatoïde, l'ostéoarthrite, l'accident vasculaire cérébral et les blessures de reperfusion cardiaque, la douleur (par ex. la douleur aiguë, la douleur inflammatoire aiguë et chronique, et la douleur neuropathique), au moyen d'un composé de formule (IA).

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