Isothiazolo-pyrimidinedione derivatives as trpa1 modulators

Details Isothiazolo-pyrimidinedione derivatives as trpa1 modulators Isothiazolo-pyrimidinedione derivatives as trpa1 modulators

C - Chemistry, Metallurgy

07

D

C07D 513/04 (2006.01) A61K 31/429 (2006.01) A61K 31/519 (2006.01) A61P 29/00 (2006.01)

Patent

CA 2756534

The present invention is related to novel isothiazolo[3,4-d] pyrimidinedione and isothiazolo[5,4-d] pyrimidine-dione derivatives as TRPA (Transient Receptor Potential subfamily A) modulators. In particular, compounds described herein are useful for treating or preventing diseases, conditions and/or disorders modulated by TRPA1 (Transient Receptor Potential subfam-ily A, member 1). Also provided herein are processes for preparing compounds described herein, intermediates used in their syn-thesis, pharmaceutical compositions thereof, and methods for treating or preventing diseases, conditions and/or disorders modulat-ed by TRPA1.

L'invention concerne de nouveaux dérivés d'isothiazolo[3,4-d] pyrimidinedione et d'isothiazolo[5,4-d] pyrimidinedione utiles comme modulateurs de la TRPA (sous-famille A des TRP). Elle concerne en particulier des composés destinés à traiter ou à prévenir des maladies, des états pathologiques et/ou des troubles modulés par TRPA1 (membre 1 de la sous-famille A des TRP). L'invention concerne aussi des procédés de préparation des composés décrits, des produits intermédiaires utiles dans la synthèse de ceux-ci, des compositions pharmaceutiques comprenant ces composés et des méthodes de traitement ou de prévention de maladies, d'états pathologiques et/ou de troubles modulés par la TRPA1.

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