Isothiazolones

C - Chemistry – Metallurgy – 07 – D

Patent

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Details

C07D 513/04 (2006.01) A61K 31/425 (2006.01) A61K 31/435 (2006.01) A61K 31/495 (2006.01) A61K 31/535 (2006.01) A61K 31/54 (2006.01) C07D 275/04 (2006.01) C07D 417/02 (2006.01) C07D 513/14 (2006.01)

Patent

CA 2218253

Isothiazolones having general structure (I) where A is a monocyclic or bicyclic ring which may contain up to 3 heteroatoms selected from O, S, and N; R1 and R2 are substituent groups such as alkyl, alkoxy, hydroxy, nitro, cyano, amino, and carboxy; and R5 is alkyl, cycloalkyl, phenyl, and Het. The isothiazolones are useful as anti-retroviral agents, anti-inflammatory agents, and anti-atherosclerotic agents.

Cette invention concerne des isothiazolones possédant la structure générale (I) où A est un noyau moncyclique ou bicyclique pouvant contenir jusqu'à 3 hétéroatomes choisis parmi O, S et N; R?1¿ et R?2¿ sont des groupes substituants tel qu'alkyle, alcoxy, hydroxy, nitro, cyano, amino et carboxy; et R?5¿ représente alkyle, cycloalkyle, phényle et Het. Ces isothiazolones sont utiles en qualité d'agents anti-rétroviraux, d'agents anti-inflammatoires et d'agents anti-athéroscléreux.

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