Isotopically labeled trapping agent and method for...

Details Isotopically labeled trapping agent and method for... Isotopically labeled trapping agent and method for...

C - Chemistry, Metallurgy

07

K

C07K 5/00 (2006.01) C07K 5/037 (2006.01) C07K 5/09 (2006.01) C07K 5/093 (2006.01)

Patent

CA 2664904

The present invention is directed to an isotopically labeled trapping agent, methods for detecting reactive metabolites and methods of identifying drug candidates. More specifically, the isotopically labeled trapping agent and methods for detecting reactive metabolites may be used to detect both " hard" and " soft" reactive metabolities, thereby elminating false positives.

La présente invention concerne un agent de piégeage étiqueté de manière isotopique, des procédés pour détecter des métabolites réactifs, et des procédés pour identifier des médicaments candidats. Plus spécifiquement, l'agent de piégeage étiqueté de manière isotopique et les procédés pour détecter des métabolites réactifs peuvent être utilisés pour détecter des métabolites réactifs "durs" et des métabolises réactifs "mous", éliminant ainsi des positifs erronés.

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