Isotopically marked quinoline derivatives as adenosin a3...

C - Chemistry – Metallurgy – 07 – D

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C07D 215/54 (2006.01) A61K 31/435 (2006.01) A61K 51/04 (2006.01) A61P 25/00 (2006.01) A61P 43/00 (2006.01) C07D 409/12 (2006.01) C07F 7/22 (2006.01)

Patent

CA 2588073

The invention relates to adenozin A3 receptor ligands labeled with iodine isotops of mass number 125, within those favourably to antagonists and their isomers, to the experimental materials containing them, to a process for the preparation of the compounds of the general formula (I) and their isomers, to the new intermediates of the general formula (II) and to the preparation thereof.

La présente invention a pour objet des ligands du récepteur de l~adénosine A3 marqués à l~aide d~iode-125, plus particulièrement des antagonistes et isomères d'antagonistes dudit récepteur. La présente invention a également pour objet les milieux expérimentaux contenant lesdits récepteurs, un procédé de préparation des composés de formule générale (I) et de leurs isomères, de nouveaux intermédiaires de formule générale (II) et un procédé de préparation de ceux-ci.

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