Isoxazole-3-carboxamide derivatives

Details Isoxazole-3-carboxamide derivatives Isoxazole-3-carboxamide derivatives

C - Chemistry, Metallurgy

07

D

C07D 261/18 (2006.01) A61K 31/42 (2006.01) A61K 31/422 (2006.01) A61K 31/4439 (2006.01) A61K 31/4453 (2006.01) A61K 31/4468 (2006.01) A61K 31/45 (2006.01) A61K 31/5377 (2006.01) A61P 25/00 (2006.01) C07D 413/06 (2006.01) C07D 413/12 (2006.01)

Patent

CA 2749856

The present invention relates to isoxa-zole-3-carboxamide derivative having the general Formula I or a pharmaceutically acceptable salt there-of, to pharmaceutical compositions comprising the same, as well as to the use of said isoxazole-3-carbox-amide derivatives for the treatment of TRPV1 mediat-ed disorders, such as acute and chronic pain disor-ders, acute and chronic neuropathic pain, acute and chronic inflammatory pain, respiratory diseases, and lower urinary tract disorders.

La présente invention porte sur un dérivé d'isoxazole-3-carboxamide répondant à la formule générale I ou sur un sel pharmaceutiquement acceptable de celui-ci, sur des compositions pharmaceutiques comprenant celui-ci, ainsi que sur l'utilisation desdits dérivés d'isoxazole-3-carboxamide pour le traitement de troubles médiés par TRPV1, tels que les troubles de douleur aiguë et chronique, la douleur neuropathique aiguë et chronique, la douleur inflammatoire aiguë et chronique, des maladies respiratoires et des maladies du tractus urinaire inférieur.

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