Isoxazole and isothiazole compounds for the treatment of...

C - Chemistry – Metallurgy – 07 – D

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C07D 417/12 (2006.01) C07D 261/14 (2006.01) C07D 413/06 (2006.01) C07D 413/12 (2006.01)

Patent

CA 2524511

The present invention relates to compounds of the Formula I wherein R3, R5, R6, R7, X, Y and Z are as defined. Compounds of the Formula I have activity 5 inhibiting production of A.beta.-peptide. This invention also relates to pharmaceutical compositions and methods of treating diseases, for example, neurodegenerative diseases, e.g., Alzheimer's disease, in a mammal comprising compounds of the Formula I.

La présente invention se rapporte à des composés répondant à la formule (I), dans laquelle R?3¿, R?5¿, R?6¿, R?7¿, X, Y et Z ont les définitions données dans la description. Les composés répondant à la formule (I) présentent une activité inhibitrice de la production du peptide A.beta.. La présente invention se rapporte également à des compositions pharmaceutiques et à des procédés de traitement chez les mammifères de maladies telles que les maladies neurodégénératives, par exemple la maladie d'Alzheimer, à l'aide de composés répondant à la formule (I).

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