Isoxazole derivative, processes for its preparation,...

Details Isoxazole derivative, processes for its preparation,... Isoxazole derivative, processes for its preparation,...

C - Chemistry, Metallurgy

07

D

260/311.9

C07D 261/18 (2006.01)

Patent

CA 1129867

Abstract of the Disclosure 5-Methylisoxazole-4-carboxylic acid(4-trifluoromethyl)- anilide and a process for its preparation in which 4-trifluoro- methylaniline is reacted with a 5-methylisoxazole-4-carboxylic acid derivative or it is reacted with diketene or a reactive acetoacetic acid derivative, the resulting acetoacetic acid 4-trifluoromethylanilide is heated with an orthoformic acid ester and the resulting 2-alkoxymethylene-acetoacetic acid 4- trifluoromethyl-anilide is reacted with hydroxyl amine. The compound has an antirheumatic, antiphlogistic, antipyretic and analgesic action, and can be used for the treatment of multiple sclerosis.

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