Isoxazole derivatives

C - Chemistry – Metallurgy – 07 – D

Patent

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Details

C07D 261/20 (2006.01) A61K 31/41 (2006.01) A61K 31/435 (2006.01) A61K 31/495 (2006.01) A61K 31/535 (2006.01) C07D 498/04 (2006.01) C07D 513/04 (2006.01)

Patent

CA 2198457

An isoxazole derivative represented by general formula (I), having an excellent monoamine oxidase inhibitory activity, and being useful as a remedy or preventive for nervous diseases such as Parkinson's diseases, wherein R1 represents hydrogen, halogen, alkyl, alkoxy, hydroxy, alkylthio, amino, alkanoyl, alkanoylamino, alkanoyloxy, alkoxycarbonyl, carboxy, (alkylthio)- thiocarbonyl, carbamoyl, nitro or cyano; R2 represents amino; m represents an integer of 1 to 3; n represents an integer of 1 to 6; ring A represents benzene, naphthalene or aromatic heterocycle; and X represents oxygen or sulfur.

L'invention concerne un dérivé isoxazole représenté par la formule générale (I) qui présente une excellente activité inhibitrice vis-à-vis de la monoamine oxydase et qui est utile comme médicament préventif ou curatif contre des maladies nerveuses, telles que la maladie de Parkinson. Dans la formule (I), R?1¿ représente un hydrogène, un halogène, un groupe alkyle, alcoxy, hydroxy, alkylthio, amino, alcanoyle, alcanoylamino, alcanoyloxy, alcoxycarbonyle, carboxy, (alkylthio)thiocarbonyle, carbamoyle, nitro ou cyano; R?2¿ représente un amino; m représente un nombre entier entre 1 et 3; n représente un nombre entier entre 1 et 6; le cycle A représente un benzène, un naphtalène ou un hétérocycle aromatique; et X représente oxygène ou soufre.

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