Isoxazole derivatives

Details Isoxazole derivatives Isoxazole derivatives

C - Chemistry, Metallurgy

07

D

C07D 417/12 (2006.01) A61K 31/42 (2006.01) A61K 31/425 (2006.01) A61K 31/435 (2006.01) A61K 31/495 (2006.01) A61K 31/53 (2006.01) A61K 31/535 (2006.01) A61K 31/54 (2006.01) A61K 31/55 (2006.01) C07D 261/14 (2006.01) C07D 413/06 (2006.01) C07D 413/10 (2006.01) C07D 413/12 (2006.01) C07D 417/06 (2006.01)

Patent

CA 2235298

An isoxazole derivative represented by the formula: Image [wherein D is a hydrogen atom, a halogen atom, a hydroxyl group or the like; one of A and B is a group represented by the formula: Image (wherein E is a single bond or an alkylene group, one of the two broken lines represents a double bond together with the solid line, while the other represents a single bond together with the other solid line. R1 is bonded to the nitrogen atom bonded through the single bond represented by the broken line and the solid line, and R1, R2, R3 and R4 are independently a hydrogen atom, a halogen atom, a hydroxyl group or the like); and the other of A and B is a group represented by the formula: -J-G (wherein G is a substituted or unsubstituted aryl group or the like, and J is -C(R8R9)- or -C(=CR8R9)- (wherein R8 and R9 are independently a hydrogen atom, a sub-stituted or unsubstituted lower alkoxy group, or the like))] or a pharmaceutically acceptable salt thereof is useful as, for example, a therapeutic drug for auto-immune diseases, inflammatory diseases, etc.

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