Isoxazole derivatives as calcium channel blockers

Details Isoxazole derivatives as calcium channel blockers Isoxazole derivatives as calcium channel blockers

C - Chemistry, Metallurgy

07

D

C07D 413/06 (2006.01) A61K 31/42 (2006.01) A61K 31/496 (2006.01) C07D 261/08 (2006.01) C07D 261/18 (2006.01)

Patent

CA 2643924

Methods and compounds effective in ameliorating conditions characterized by unwanted calcium channel activity, particularly unwanted N-type or T-type calcium channel activity are disclosed. Specifically, a series of isoxazole containing compounds are disclosed of the general formula (1) where Z is N or CHNR3 and (Ar1)2CR4 is optionally substituted benzhydryl.

La présente invention concerne des procédés et des composés efficaces dans l'amélioration de conditions caractérisées par une activité indésirable du canal calcique, notamment une activité indésirable du canal calcique de type N ou de type T. Des manière spécifique, l'invention concerne une série de composés contenant de l'isoxazole de formule générale (1) dans laquelle Z est N ou CHNR3 et (Ar1)2CR4 est éventuellement du benzhydryle substitué.

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