C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 413/06 (2006.01) A61K 31/454 (2006.01) A61P 27/00 (2006.01)
Patent
CA 2711708
The present invention relates to novel isoxazole compounds of formula (I), and pharmaceutically acceptable salts, solvates, hydrates, geometrical isomers, tautomers, optical isomers or N-oxides thereof, which are modulators of 11.beta.-hydroxysteroid dehydrogenase type 1(11.beta.-HSD1). The invention also relates to pharmaceutical compositions comprising these compounds and to the use of these compounds in the preparation of a medicament for the treatment of glaucoma.
La présente invention concerne de nouveaux composés d'isoxazole de formule (I), et leurs sels pharmaceutiquement acceptables, solvates, hydrates, isomères géométriques, tautomères, isomères optiques ou N-oxydes, qui sont des modulateurs de la 11-ß-hydroxystéroïde déshydrogénase de type 1 (11ß-HSD1). L'invention concerne également des compositions pharmaceutiques renfermant ces composés et l'utilisation de ces composés dans la préparation d'un médicament destiné au traitement du glaucome.
Bystroem Styrbjoern
Haraldsson Martin
Johansson Lars
Tejbrant Jan
Biovitrum Ab (publ)
Fetherstonhaugh & Co.
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