C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
167/208, 260/304
C07D 261/00 (2006.01) A61K 31/42 (2006.01) C07D 261/12 (2006.01) C07D 261/20 (2006.01) C07D 413/12 (2006.01)
Patent
CA 1337198
Compounds of formula (I): Image (I) [in which: either (a) the dotted line (---) is a single bond; A= is oxygen; and B is a group of formula (II): Image (II) (in which m is 0 and n is 0 or 1) or (b) the dotted line (---) is a double bond; A= is said group of formula (II) in which m is 1 and n is 0 or l; and B is absent; and R1 is hydrogen, halogen, alkyl, alkenyl, alkynyl, optionally substituted benzyl or optionally substituted phenyl; R2 is hydrogen, halogen, alkyl, optionally substituted phenyl or heterocyclic or R1 and R2, together with the carbon atoms to which they are attached, are a hydrocarbon ring fused to the isoxazole ring; R3 and R4 are each hydrogen, alkyl, optionally substituted benzyl or optionally substituted phenyl; or R3, R4 and the nitrogen atom to which they are attached together represent an alicyclic amino group]; and salts thereof may be used for the treatment of cerebral circulatory problems and for use as centrally acting muscle relaxants.
595231
Iwata Nobutoshi
Kato Katsunori
Kobayashi Kazuo
Kozuka Masao
Kubo Yoshiko
Marks & Clerk
Sankyo Company Limited
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