C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 413/14 (2006.01) A61K 31/422 (2006.01) A61K 31/427 (2006.01) A61K 31/4439 (2006.01) A61P 25/28 (2006.01) C07D 261/06 (2006.01) C07D 417/14 (2006.01)
Patent
CA 2749649
The present invention is concerned with isoxazole-isoxazole and isoxazole- isothiazole derivatives of Formula (I), having affinity and selectivity for GABA A .alpha.5 receptor, their manufacture, pharmaceutical compositions containing them and their use as medicaments. The active compounds of the present invention are useful as cognitive enhancer or for the therapeutic and/or prophylactic treatment of cognitive disorders like Alzheimer's disease.
La présente invention concerne des dérivés isoxazole-isoxazole et isoxazole-isothiazole de formule (I), présentant une affinité et une sélectivité pour le récepteur alpha5-GABAA, leur fabrication, les compositions pharmaceutiques les contenant et leur utilisation comme médicaments. Les composés actifs de la présente invention sont utiles comme amplificateur cognitif ou pour le traitement thérapeutique et/ou prophylactique de troubles cognitifs tels que la maladie d'Alzheimer.
Hernandez Maria-Clemencia
Jakob-Roetne Roland
Lucas Matthew C.
Thomas Andrew
Borden Ladner Gervais Llp
F.hoffmann-La Roche Ag
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