C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 413/12 (2006.01)
Patent
CA 2760597
The present invention is concerned with isoxazole-pyridazine derivatives of Formula (I), having affinity and selectivity for GABA A a5 receptor, their manufacture, pharmaceutical compositions containing them and their use as therapeutically active substances. The active compounds of the present invention are useful as cognitive enhancer or for the therapeutic and/or prophylactic treatment of cognitive disorders like Alzheimer's disease.
La présente invention a pour objet des dérivés d'isoxazole-pyridazine de Formule (I), ayant une affinité et une sélectivité pour le récepteur GABA A a5, leur fabrication, des compositions pharmaceutiques les contenant et leur utilisation en tant que substances thérapeutiquement actives. Les composés actifs de la présente invention sont utiles en tant qu'amplificateur cognitif ou pour le traitement thérapeutique et/ou prophylactique de troubles cognitifs comme la maladie d'Alzheimer.
Lucas Matthew C.
Thomas Andrew
Borden Ladner Gervais Llp
F. Hoffmann-La Roche Ag
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