C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 413/12 (2006.01) A61K 31/4439 (2006.01) A61P 25/00 (2006.01) A61P 25/18 (2006.01) A61P 25/22 (2006.01) A61P 25/28 (2006.01) C07D 413/14 (2006.01)
Patent
CA 2757412
The present invention is concerned with novel isoxazole derivatives of formula (I) wherein X, R1, R2, R3 and R4 are as described herein, as well as pharmaceutically acceptable salts and esters thereof. The active compounds of the present invention have affinity and selectivity for GABA A .alpha.5 receptor. Further the present invention is concerned with the manufacture of the active compounds of formula (I), pharmaceutical compositions containing them and their use as medicaments.
La présente invention concerne de nouveaux dérivés d'isoxazole de formule (I) dans lesquels X, R1, R2, R3 et R4 sont comme présentement décrits, ainsi que des sels pharmaceutiquement acceptables et des esters de ceux-ci. Les composés actifs de la présente invention ont une affinité et une sélectivité pour un récepteur de GABA Aa5. La présente invention concerne en outre la fabrication des composés actifs de formule (I), des compositions pharmaceutiques contenant ceux-ci et leur utilisation en tant que médicaments.
Buettelmann Bernd
Jakob-Roetne Roland
Knust Henner
Lucas Matthew C.
Thomas Andrew
Borden Ladner Gervais Llp
F. Hoffmann-La Roche Ag
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