C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 417/14 (2006.01) A61K 31/4245 (2006.01) A61P 25/00 (2006.01) C07D 413/12 (2006.01) C07D 413/14 (2006.01)
Patent
CA 2494987
The present invention relates to new compounds of formula (I), a process for their preparation and new intermediates prepared therein, pharmaceutical formulations containing said compounds and to the use of said compounds in therapy. In particular, there are compounds according to the present invention that are potent and selective for the mGluR Group I receptor and more particularly for mGluR5. Thus, it is expected that the compounds of the invention are well suited for the prevention and/or treatment of mGluR5 receptor-mediated disorders such as acute and chronic neurological and psychiatric disorders and chronic and acute pain disorders.
La présente invention se rapporte à de nouveaux composés représentés par la formule (I), à leur procédé de préparation et à de nouveaux intermédiaires préparés par ledit procédé, ainsi qu'à des préparations pharmaceutiques contenant lesdits composés et à l'utilisation thérapeutique de ces derniers.
Arora Jalaj
Edwards Louise
Gyback Helena
Isaac Methvin
Johansson Martin
Astrazeneca Ab
Bereskin & Parr Llp/s.e.n.c.r.l.,s.r.l.
Nps Pharmaceuticals Inc.
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