Isoxazoline compositions and their use as antiparasitics

A - Human Necessities – 61 – K

Patent

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Details

A61K 31/42 (2006.01) A61K 31/427 (2006.01) A61K 31/4439 (2006.01) A61K 31/497 (2006.01) A61K 31/506 (2006.01) A61P 33/14 (2006.01)

Patent

CA 2694919

This invention relates to methods for controlling parasitic infestations of animals and their environments, and, more particularly, to methods using isoxazolines to control parasites in or on animals or in their environments, as well as treat parasitoses of animals. The isoxazolines include 4-(isoxazolinyl)-benzamides (specifically, substituted 4-(5-(halomethyl)-5-phenylisoxazolin-3-yl)- benzamides) and 4-(isoxazolinyl)-benzothioamides (specifically, substituted 4-(5- (halomethyl)-5-phenyl-isoxazolin-3-yl)-benzothioamides). This invention also relates to compositions comprising the isoxazolines for use in such methods, the use of the isoxazolines to make medicaments for use in such methods, and kits comprising the isoxazolines for carrying out such methods. This invention further relates to the use of the isoxazolines as medicaments, particularly medicaments that can be used in the above-referenced method.

Cette invention porte sur des procédés pour lutter contre des infestations parasitaires d'animaux et leurs environnements, et, plus particulièrement, sur des procédés utilisant des isoxazolines pour lutter contre les parasites dans ou sur des animaux ou dans leurs environnements, ainsi que pour traiter des parasitoses d'animaux. Les isoxazolines comprennent les 4-(isoxazolinyl)-benzamides (notamment, les 4-(5-(halométhyl)-5-phényl-isoxazolin-3-yl)-benzamides substitués) et les 4-(isoxazolinyl)-benzothioamides (notamment, les 4-(5-(halométhyl)-5-phényl-isoxazolin-3-yl)-benzothioamides substitués). Cette invention porte également sur des compositions comprenant les isoxazolines pour une utilisation dans de tels procédés, sur l'utilisation des isoxazolines pour fabriquer des médicaments destinés à être utilisés dans de tels procédés, et sur des kits comprenant les isoxazolines pour la mise en uvre de tels procédés. Cette invention porte en outre sur l'utilisation dans des isoxazolines en tant que médicaments, en particulier des médicaments qui peuvent être utilisés dans le procédé mentionné ci-dessus.

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