Isoxazoline compounds as 5-lipoxygenase inhibitors

Details Isoxazoline compounds as 5-lipoxygenase inhibitors Isoxazoline compounds as 5-lipoxygenase inhibitors

A - Human Necessities

61

K

A61K 31/42 (2006.01) A61K 31/47 (2006.01)

Patent

CA 2184914

This invention relates to isoxazoline compounds which are inhibitors of 5-lipoxygenase (5-LO). The isoxazoline compounds are useful in the treatment or alleviation of inflammatory disease, allergy and cardiovascular diseases, wherein the inflammatory disease or condition is asthma, arthritis, bronchitis, chronic obstructive pulmonary disease, psoriasis, allergic rhinitis, dermatitis, shock, atopic dermatitis rheumatoid arthritis and osteoarthritis. This invention also relates to pharmaceutical compositions useful therefor.

L'invention se rapporte à des composés d'isoxazoline agissant comme inhibiteurs de 5-lipoxygénase (5-LO). Ces composés conviennent au traitement ou à l'atténuation des maladies inflammatoires, des allergies et des maladies cardiovasculaires, des troubles ou maladies inflammatoires comprenant notamment l'asthme, les bronchites, les bronchopneumopathies chroniques obstructives, le psoriasis, les rhinites allergiques, les dermatites, les chocs, les dermatites atopiques, la polyarthrite rhumatoïde et l'arthrose. L'invention se rapporte également à des compositions pharmaceutiques convenant à de tels traitements.

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