Isoxazoline compounds as antiinflammatory agents

C - Chemistry – Metallurgy – 07 – D

Patent

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Details

C07D 261/04 (2006.01) A61K 31/42 (2006.01) A61K 31/47 (2006.01) C07D 413/12 (2006.01)

Patent

CA 2176255

This invention relates to new isoxazoline compounds which are selective inhibitors of phosphodiesterase type IV (PDErv). The new isoxazoline compounds are useful in inhibiting PDErv and in the treatment of AIDS, asthma, arthritis, bronchitis, chronic obstructive pulmonary disease, psoriasis, allergic rhinitis, dermatitis, shock, atopic dermatitis, rheumatoid arthritis and osteroarthritis. This invention also relates to pharmaceutical compositions useful therefor.

La présente invention se rapporte à des nouveaux composés d'isoxazoline qui sont des inhibiteurs sélectifs de la phosphodiestérase de type IV (PDE¿IV?) et sont utiles dans le traitement du SIDA, de l'asthme, de l'arthrite, de la bronchite, de la broncho-pneumopathie chronique obstructive, du psoriasis, de la rhinite allergique, des dermatites, du choc septique, de l'eczéma constitutionnel, de l'arthrite rhumatoïde et de l'arthrose. L'invention se rapporte également aux compositions pharmaceutiques utiles dans ces indications.

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