C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 261/04 (2006.01) A61K 31/395 (2006.01) C07D 413/12 (2006.01)
Patent
CA 2174415
This invention relates to novel isoxazolines which are useful as antagonists of the platelet glycoprotein IIb/IIIa fibrinogen receptor complex, to pharmaceutical compositions containing such compounds, processes for preparing such compounds, and to methods of using these compounds, alone or in combination with other therapeutic agents, for the inhibition of platelet aggregation, as thrombolytics, and/or for the treatment of thromboembolic disorders,
Cette invention se rapporte à des nouvelles isoxazolines utiles en tant qu'antagonistes du complexe récepteur fibrinogène IIb/IIIa de la glycoprotéine des plaquettes; elle se rapporte également aux compositions pharmaceutiques contenant de tels composés, aux procédés de préparations de ces composés, ainsi qu'aux méthodes d'utilisation de ceux-ci, seuls ou en combinaison avec d'autres agents thérapeutiques -tels que les thrombolytiques- pour inhiber l'agrégation plaquettaire et/ou pour traiter les troubles de la thrombo-embolie.
Sielecki-Dzurdz Thais Motria
Wityak John
Bristol-Myers Squibb Pharma Company
Dimock Stratton Llp
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