C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 413/06 (2006.01) A61K 31/42 (2006.01) A61P 7/02 (2006.01)
Patent
CA 2345342
This invention relates to novel isoxazolines of formula (I) or a pharmaceutically acceptable salt form thereof. This invention also relates to novel isoxazolines of formula (I) which are useful as antagonists of the platelet glycoprotein IIb/IIIa fibrinogen receptor complex, to pharmaceutical compositions containing such compounds, processes for preparing such compounds, and to methods of using these compounds, alone or in combination with other therapeutic agents, for the inhibition of platelet aggregation, as thrombolytics, and/or for the treatment of thromboembolic disorders.
L'invention concerne de nouvelles isoxazolines correspondant à la formule (I) ou à une forme de sel pharmaceutiquement acceptable de celles-ci. L'invention concerne aussi de nouvelles isoxazolines correspondant à la formule (I) utiles en tant qu'antagonistes du complexe récepteur de fibrinogène IIb/IIIa de glycoprotéine plaquettaire, des compositions pharmaceutiques contenant ces composés, des procédés de préparation de ces composés et des procédés de leur utilisation, isolément ou en combinaison avec d'autres agents thérapeutiques, à des fins d'inhibition de l'agrégation plaquettaire, en tant qu'agents thrombolytiques et/ou dans le traitement de troubles thromboemboliques.
Jadhav Prabhakar K.
Wityak John
Bristol-Myers Squibb Pharma Company
Dimock Stratton Clarizio Llp
Dupont Pharmaceuticals Company
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