Isoxazolone compounds useful in treating diseases associated...

C - Chemistry – Metallurgy – 07 – D

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C07D 413/14 (2006.01) A61K 31/34 (2006.01) A61K 31/395 (2006.01) A61K 31/41 (2006.01) A61K 31/42 (2006.01) A61K 31/4245 (2006.01) A61K 31/44 (2006.01) A61K 31/445 (2006.01) A61K 31/495 (2006.01) A61K 31/505 (2006.01) A61K 31/506 (2006.01) A61K 31/53 (2006.01) A61K 31/535 (2006.01) A61P 19/02 (2006.01) A61P 29/00 (2006.01) C07D 413/04 (2006.01)

Patent

CA 2446801

Isoxazolone compounds having the generic structure: are used to treat disease associated with unwanted cytokine activity, including rheumatoid arthritis, osteoarthritis, diabetes, HIV/AIDS, inflammatory bowel disease, Crohn's disease, ulcerative colitis, congestive heart, hypertension, chronic obstructive pulmonary disease, septic shock syndrome, tuberculosis, adult respiratory distress, asthma, atherosclerosis, muscle degeneration, periodontal disease, cachexia, Reiter's syndrome, gout, acute synovitis, anorexia and bulimia nervosa fever, malaise, myalgia and headaches.

Composés d'isoxazolone de structure générique (I) utilisés pour traiter des maladies associées à un activité non désirée des cytokines, dont la polyarthrite rhumatoïde, l'arthrose, le diabète, le VIH/SIDA, les infections intestinales inflammatoires, la maladie de Crohn, la rectocolite hémorragique, l'insuffisance cardiaque congestive, l'hypertension, la bronchopneumopathie chronique obstructive, le choc septique, la tuberculose, le syndrome de détresse respiratoire de l'adulte, l'asthme, l'athérosclérose, la dégénérescence musculaire, la maladie desmodontale, la cachexie, le syndrome oculo-urétrosynovial, la goutte, la synovite aiguë, l'anorexie et la boulimie, les malaises, la myalgie et les céphalées.

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