C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 413/14 (2006.01) A61K 31/506 (2006.01) A61P 35/02 (2006.01) A61P 37/00 (2006.01) C07D 413/04 (2006.01)
Patent
CA 2452603
The present invention provides compounds of formula I or a pharmaceutically acceptable derivative thereof, wherein A-B is N-O or O-N and G, R1, R2, R3, and R4 are as described in the specification. These compounds are inhibitors of protein kinase, particularly inhibitors of Src and Lck kinase. The invention also provides pharmaceutical compositions comprising the inhibitors of the invention and methods of utilizing those compositions in the treatment and prevention of various disorders.
La présente invention se rapporte à des composés représentés par la formule (I) ou à un dérivé pharmaceutiquement acceptable de ces composés. Dans la formule (I) A-B est N-O ou O-N et G, R?1¿, R?2¿, R?3¿ et R?4¿ sont décrits dans la spécification. Ces composés sont des inhibiteurs des protéines kinases, particulièrement des inhibiteurs des kinases Src et Lck. L'invention se rapporte également à des compositions pharmaceutiques contenant ces inhibiteurs ainsi qu'à des procédés d'utilisation de ces compositions pour le traitement et la prévention de divers troubles.
Bemis Guy
Gao Huai
Harrington Edmund
Ledeboer Mark
Salituro Francesco
Smart & Biggar
Vertex Pharmaceuticals Incorporated
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