Itraconazole compositions with improved bioavailability

Details Itraconazole compositions with improved bioavailability Itraconazole compositions with improved bioavailability

A - Human Necessities

61

K

A61K 9/14 (2006.01) A61K 31/496 (2006.01)

Patent

CA 2618255

A solid dispersion product comprising itraconazole and hydroxypropyl methylcellulose, which satisfies the Formula 0.35 > .DELTA.Htr (1) (wherein .DELTA.Htr represents the endotherm (J/g) accompanying a transition at about 240~ C). The solid dispersion product shows an improved bioavailability.

L'invention concerne un produit de dispersion solide comprenant de l'itraconazole et de l'hydroxypropyl méthylcellulose, et satisfaisant à la formule 0,35 > ?Htr (1) (dans laquelle ?Htr représente l'endotherme (J/g) accompagnant une transition à environ 240°C). Ce produit de dispersion solide présente une biodisponibilité améliorée.

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