C - Chemistry – Metallurgy – 12 – Q
Patent
C - Chemistry, Metallurgy
12
Q
C12Q 1/68 (2006.01)
Patent
CA 2695972
The present invention provides methods for providing a prognosis of treatment of diseases associated with inflammatory disease of the brain, including MS, e.g., relapsing- remitting multiple sclerosis (RRMS), Alzheimer's disease, and Parkinson's disease using molecular markers that are shown to he overexpressed or underexpressed in patients treated with intravenous immunoglobulins (IVIG). Also provided are methods to identify compounds that are useful for the treatment or prevention of MS, e.g., relapsing-remitting multiple sclerosis (RRMS), Alzheimer's disease, and Parkinson's disease.
La présente invention concerne des méthodes permettant de poser un pronostic pour un traitement de maladies associées à une maladie inflammatoire du cerveau, tels que la sclérose en plaques, par exemple, la sclérose en plaques rémittente (RRMS), la maladie d'Alzheimer et la maladie de Parkinson à l'aide de marqueurs moléculaires qui se sont surexprimés ou sous-exprimés chez des patients traités par des immunoglobulines intraveineuses. L'invention porte également sur des procédés pour identifier des composés utiles pour le traitement ou la prévention de la sclérose en plaques, par exemple, la sclérose en plaques rémittente (RRMS), la maladie d'Alzheimer et la maladie de Parkinson.
Ehrlich Hartmut
Elovaara Irina
Reipert Birgit
Schwarz Hans-Peter
Baxter Healthcare S.a.
Baxter International Inc.
Sim & Mcburney
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