Jak inhibitors for treatment of myeloproliferative disorders

Details Jak inhibitors for treatment of myeloproliferative disorders Jak inhibitors for treatment of myeloproliferative disorders

A - Human Necessities

61

K

A61K 31/553 (2006.01) A61P 43/00 (2006.01)

Patent

CA 2658192

The invention provides a method for treating myeloproliferative disorders, myelodysplastic syndromes and other diseases, in which activation of JAK2 contributes to pathology, in a mammal comprising administering to the mammal an effective amount of a fused pyrrolocarbazole derivative wherein the fused pyrrolocarbazole derivative inhibits the activity of JAK2.

La présente invention concerne un procédé de traitement des syndromes myéloprolifératifs, des syndromes myélodysplasiques et d'autres maladies dans lesquelles l'activation de la JAK2 contribue à la pathologie chez un mammifère. Ledit procédé comprend l'administration au mammifère d'une quantité efficace d'un dérivé fusionné du pyrrolocarbazole, ledit dérivé fusionné du pyrrolocarbazole inhibant l'activité JAK2.

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