Jak kinases and regulation of cytokine signal transduction

Details Jak kinases and regulation of cytokine signal transduction Jak kinases and regulation of cytokine signal transduction

C - Chemistry, Metallurgy

12

N

C12N 15/54 (2006.01) A61K 31/00 (2006.01) A61K 31/35 (2006.01) A61K 31/70 (2006.01) A61K 38/45 (2006.01) A61K 39/395 (2006.01) A61K 48/00 (2006.01) C07K 16/40 (2006.01) C12N 5/10 (2006.01) C12N 9/12 (2006.01) C12Q 1/48 (2006.01) C12Q 1/68 (2006.01) G01N 33/573 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2168098

Provided are methods for regulating the cellular response to cytokines by inhibiting or enhancing of at least one Jak kinase activity which mediates the response; assays for identifying inhibitors of Jak kinase activity or cytokine-induced Jak kinase activation useful in the methods of the invention are also provided; antibodies raised against peptide fragments of at least one epitope specific for a Jak kinase without interfering with kinase activity; polypeptides for Jak kinases; and nucleic acid encoding therefor.

Cette invention concerne des procédés de régulation de la réponse cellulaire à des cytokines par inhibition ou renforcement d'au moins une activité de kinase Jak qui assure la réponse; des déterminations permettant d'identifier des inhibiteurs de l'activité de la kinase Jak ou de l'activation de la kinase Jak induite par la cytokine qui sont utiles dans les procédés de cette invention; des anticorps dirigés contre des fragments peptidiques d'au moins un déterminant antigénique spécifique contre une kinase Jak sans qu'il y ait interférence avec l'activité de la kinase; des polypeptides destinés aux kinases Jak; et de l'acide nucléique de codage approprié.

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