C - Chemistry – Metallurgy – 07 – K
Patent
C - Chemistry, Metallurgy
07
K
C07K 1/00 (2006.01) A61K 39/00 (2006.01) A61K 39/295 (2006.01) C07K 1/04 (2006.01) C07K 1/10 (2006.01) C07K 14/76 (2006.01) C07K 19/00 (2006.01)
Patent
CA 2406472
The present invention relates to antigenic complexes, wherein an antigenic complex comprises a peptide or protein containing a plurality of epitopes non- covalently joined to a heat shock protein via a molecular tether referred to as a "javelin". Such complexes do not require that each epitope Be defined, and may, in certain embodiments, elicit both antibody and cell-mediated immune reactions. The complexes of the invention may be used to induce therapeutic immune responses directed toward the treatment or prevention of infectious diseases and malignancies.
L'invention concerne des complexes antigéniques dans lesquels un peptide ou une protéine contenant de nombreux épitopes est lié, de manière non covalente, à une protéine de stress via une attache moléculaire appelée "javelot". De tels complexes ne requièrent pas une définition de chaque épitope et peuvent, dans certaines réalisations, provoquer des réactions immunes à la fois d'anticorps et à médiation cellulaire. Les complexes de l'invention peuvent être utilisés afin d'induire des réponses immunes thérapeutiques en vue de traitement ou de prévention de maladies infectieuses et de malignités.
Hoe Mee
Mayhew Mark
Rothman James E.
Hoe Mee
Mayhew Mark
Rothman James E.
Smart & Biggar
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