Jnk inhibitors

Details Jnk inhibitors Jnk inhibitors

A - Human Necessities

61

K

A61K 31/497 (2006.01) A61K 31/416 (2006.01) A61K 31/4439 (2006.01) A61K 31/444 (2006.01) A61P 25/28 (2006.01) C07D 231/56 (2006.01) C07D 401/06 (2006.01)

Patent

CA 2508319

A JNK inhibitor which contains as an active ingredient either an indazole derivative represented by the formula (I): (I) [wherein R1 represents (un)substituted aryl, etc.; and R2 represents hydrogen, NR3R4 (wherein R3 and R4 are the same or different and each represents hydrogen, (un)substituted lower alkanoyl, etc.), carboxy, lower alkenyl, etc.] or a pharmacologically acceptable salt of the derivative.

L'invention se rapporte à un inhibiteur de JNK qui contient en tant qu'ingrédient actif soit un dérivé indazole représenté par la formule (I), dans laquelle R?1¿ représente un aryle (non) substitué, etc. ; et R?2¿ représente hydrogène, NR?3¿R?4¿ (où R?3 ¿et R?4 ¿sont identiques ou différents et représentent chacun hydrogène, alcanoyle inférieur (non)substitué, etc.), carboxy, alcényle inférieur, etc., soit un sel pharmaceutiquement acceptable de ce dérivé.

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