Jnk3 modulators and methods of use

Details Jnk3 modulators and methods of use Jnk3 modulators and methods of use

C - Chemistry, Metallurgy

12

N

C12N 5/10 (2006.01) C12N 5/0735 (2010.01) C12N 15/873 (2010.01) A01K 67/027 (2006.01) A61K 31/7088 (2006.01) A61K 48/00 (2006.01) C12N 15/09 (2006.01) C12N 15/54 (2006.01) C12Q 1/48 (2006.01) G01N 33/573 (2006.01) C12N 9/12 (2006.01)

Patent

CA 2302874

The c-Jun NH2-terminal kinase (JNK) group of MAP kinases are activated by exposure of cells to environmental stress. The role of JNK in the brain was examined by targeted disruption of the gene that encodes the neuronal isoform JNK3. It was found that JNK3 is required for the normal response to seizure activity. Methods of screening for molecules and compounds that decrease JNK3 expression or activity are described. Such molecules or compounds are useful for treating disorders involving excitotoxicity such as seizure disorders, Alzheimer's disease, Huntington disease, Parkinson's disease, and ischaemia.

Le groupe c-Jun NH¿2?-terminal kinase (JNK) de protéines kinases associées aux membranes est activé par exposition de cellules à une contrainte liée à l'environnement. Le rôle de JNK dans le cerveau a été examiné par rupture ciblée du gène codant l'isoforme neuronal JNK3. On a découvert que JNK3 était nécessaire dans la réponse normale à une crise. L'invention concerne des méthodes de criblage de molécules et de composés réduisant l'expression ou l'activité de JNK3. Ces molécules ou composés s'utilisent dans le traitement de troubles impliquant une excitotoxicité tels que des troubles épileptiques, la maladie d'Alzheimer, la chorée de Huntington, la maladie de Parkinson et l'ischémie.

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