Joining and/or sealing tissues through photo-activated...

A - Human Necessities – 61 – L

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A61L 24/10 (2006.01) A61K 9/70 (2006.01) C09J 189/00 (2006.01)

Patent

CA 2640560

A method of joining and/or sealing tissues in a surgical procedure or medical treatment, comprising the steps of: (1) applying a matrix protein, a photoactivatable metal-ligand complex and an electron acceptor to a tissue portion; (2) irradiating said tissue portion to photactivate the photoactivatable metal-ligand complex; thereby initiating a cross-linking reaction of the matrix protein to seal said tissue portion or join said tissue portion to an adjacent tissue portion.

L'invention concerne une méthode de jonction et/ou d'assemblage de tissus lors d'une intervention chirurgicale ou d'un traitement médical. Les étapes de cette méthode consistent à : (1) appliquer une protéine matricielle, un complexe métal-ligand photoactivable et un accepteur d'électrons sur une portion de tissu, (2) irradier ladite portion de tissu afin de photoactiver le complexe métal-ligand photoactivable et d'amorcer ainsi une réaction de réticulation de la protéine matricielle afin de coller ladite portion de tissu ou de joindre ladite portion de tissu avec une portion de tissu adjacente.

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