K-ras and b-raf mutations and anti-egfr antibody therapy

Details K-ras and b-raf mutations and anti-egfr antibody therapy K-ras and b-raf mutations and anti-egfr antibody therapy

C - Chemistry, Metallurgy

12

Q

C12Q 1/68 (2006.01)

Patent

CA 2680330

The present application relates to K-ras mutations, to polynucleotides encoding mutant K-ras polypeptides, and to methods of identifying K-ras mutations. The present application also relates to B-raf mutations, to polynucleotides encoding mutant B-raf polypeptides, to vectors containing those polynucleotides, and to methods of identifying B-raf mutations. The present application also relates to methods of diagnosing cancer; and methods and kits for predicting the usefulness of anti-EGFr specific binding agents in the treatment of tumors.

La présente invention concerne des mutations de K-ras, des polynucléotides codant pour des polypeptides de K-ras mutants, et des procédés d'identification de mutations K-ras. La présente invention concerne également des mutations B-raf, des polynucléotides codant pour des polypeptides B-raf mutants, des vecteurs contenant ces polynucléotides, et des procédés d'identification de mutations B-raf. La présente invention concerne en outre des procédés de diagnostic du cancer; et des procédés et des trousses de prédiction de l'utilité d'agents de liaison spécifique de l'anti-EGFR dans le traitement de tumeurs.

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