Kainate-binding, human cns receptors of the eaa1 family

Details Kainate-binding, human cns receptors of the eaa1 family Kainate-binding, human cns receptors of the eaa1 family

C - Chemistry, Metallurgy

12

N

C12N 15/12 (2006.01) A61K 39/395 (2006.01) C07H 21/00 (2006.01) C07K 14/705 (2006.01) C07K 16/28 (2006.01) C12N 5/10 (2006.01) C12P 21/08 (2006.01) G01N 33/566 (2006.01) G01N 33/567 (2006.01)

Patent

CA 2076798

- ? - ABSTRACT Neurotransmission by excitatory amino acids (EAAs) such as glutamate is mediated via membrane-bound surface receptors. DNA coding for one family of these receptors, of the kainate binding type of EAA receptors, has now been isolated and the receptor protein characterized. Herein described are recombinant cell lines which produce the EAA receptor as a heterologous membrane-bound product. Also described are related aspects of the invention, which are of commercial significance. Included is use of the cell lines as a tool for discovery of compounds which modulate EAA receptor stimulation.

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