Kanamycin antisense nucleic acid for the treatment of cancer

Details Kanamycin antisense nucleic acid for the treatment of cancer Kanamycin antisense nucleic acid for the treatment of cancer

C - Chemistry, Metallurgy

12

N

C12N 15/113 (2010.01) A61K 31/7088 (2006.01)

Patent

CA 2756070

The invention relates to a nucleic acid comprising a sequence complementary to a fragment of the sequence coding for the kanamycin resistance protein. This nucleic acid is useful as a DNA vaccine adjuvant, and can be used e.g. for treating cancer, for example in combination with a non-immunosuppressive inducer of tumor cell apoptosis such as all-trans retinoic acid (ATRA).

L'invention porte sur un acide nucléique comprenant une séquence complémentaire à un fragment de la séquence codant pour la protéine de résistance à la kanamycine. Cet acide nucléique est utile comme adjuvant de vaccin à ADN et peut être utilisé par exemple pour le traitement d'un cancer, par exemple en association avec un inducteur d'apoptose de cellules tumorales non immunosuppresseur tel que l'acide tout-trans- rétinoïque (ATRA).

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