Kappa agonist compounds and pharmaceutical formulations thereof

Details Kappa agonist compounds and pharmaceutical formulations thereof Kappa agonist compounds and pharmaceutical formulations thereof

C - Chemistry, Metallurgy

07

D

C07D 241/04 (2006.01) A61K 31/16 (2006.01) A61K 31/395 (2006.01) A61K 31/40 (2006.01) A61K 31/404 (2006.01) A61K 31/4439 (2006.01) A61K 31/495 (2006.01) A61K 31/675 (2006.01) A61K 38/02 (2006.01) C07C 233/41 (2006.01) C07C 237/20 (2006.01) C07D 207/10 (2006.01) C07D 209/28 (2006.01) C07D 209/42 (2006.01) C07D 211/70 (2006.01) C07D 213/56 (2006.01) C07D 295/155 (2006.01) C07D 401/12 (2006.01) C07D 403/06 (2006.01) C07D 403/12 (2006.01) C07D 403/14 (2006.01) C07D 405/02 (2006.01) C07D 409/02 (2006.01) C07F 9/

Patent

CA 2240728

Compounds having kappa opioid agonist activity, compositions containing them and method of using them as analgesics are provided. The compounds of formulae (I), (II), (III) and (IV) have the structure wherein X, X4, X5, X7, X9; R1, R2, R3, R4; and Y, Z and n are as described in the specification.

L'invention porte sur des composés présentant une activité agoniste de l'opioïde kappa, sur des compositions les contenant et sur leurs méthodes d'utilisation comme analgésiques. Ces composés, de formules (I), (II), (III) et (IV) présentent une structure dans laquelle X, X4, X5, X7, X9, R1, R2, R3, R4; et Y, Z et n sont décrits dans la description.

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