A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 31/40 (2006.01) A61K 31/404 (2006.01) A61K 31/4439 (2006.01) A61K 31/495 (2006.01)
Patent
CA 2289055
Compounds having kappa opioid agonist activity, compositions containing them and method of using them as analgesics and anti-pruritic agents are provided. The compounds of formulae (I), (II), (III) and (IV) have structures wherein X, X4, X5, X7, X9; R1, R2, R3, R4; and Y, Z and n are as described in the specification.
Composés ayant une activité agoniste des récepteurs opioïdes kappa, compositions les contenant et procédé d'utilisation de ces composés en tant qu'analgésiques et agents anti-pruritiques. Lesdits composés sont représentés par les formules I, II, III et IV dans lesquelles X, X¿4?, X¿5?, X¿7?, X¿9?, R¿1?, R¿2?, R¿3?, R¿4? et Y, Z et n sont tels que spécifiés dans le descriptif.
Chang An-Chih
Dehaven-Hudkins Diane L.
Farrar John J.
Gaul Forrest
Kruse Lawrence I.
Adolor Corporation
Mcfadden Fincham
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