A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 31/40 (2006.01) A61P 1/00 (2006.01) A61P 1/12 (2006.01) A61P 29/00 (2006.01)
Patent
CA 2682608
The present invention concerns methods useful in treating one or more subtypes of irritable bowel syndrome (IBS), or useful in treating diarrhea. The invention relates to the use of peripherally selective kappa-opiate agonists, especially N-methyl-N-[(1S)-1-phenyl-2-((3S)-3-hydroxypyrrolidin-1-yl)ethyl]-2,2-diphenylacetamide and/or a pharmaceutically acceptable salt thereof for treating a subject having diarrhea-predominant IBS (IBS-D) or IBS with alternating diarrhea and constipation (IBS-A), or a subject having diarrhea.
La présente invention concerne des procédés utiles dans le traitement d'un ou des sous-types du syndrome du côlon irritable (IBS), ou utiles dans le traitement de la diarrhée. L'invention concerne l'utilisation d'agonistes sélectifs du récepteur opiacé kappa périphérique, en particulier le N-méthyl-N-[(1S)-1-phényl-2-((3S)-3-hydroxypyrrolidin-1-yl)éthyl]-2,2-diphénylacétamide et/ou un de ses sels pharmaceutiquement acceptables pour le traitement d'un sujet ayant un IBS à diarrhée prédominante (IBS-D) ou un IBS avec alternance entre diarrhée et constipation (IBS-A), ou un sujet ayant la diarrhée.
Fetherstonhaugh & Co.
Tioga Pharmaceuticals Inc.
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