Kappa opioid receptor ligands

Details Kappa opioid receptor ligands Kappa opioid receptor ligands

A - Human Necessities

61

K

A61K 31/4725 (2006.01) A61P 25/30 (2006.01)

Patent

CA 2714219

Kappa opioid receptor antagonists are provided that yield significant improvements in functional binding assays to kappa opioid receptors, and the use of these antagonists in treatment of disease states that are ameliorated by binding of the kappa opioid receptor such as heroin or cocaine addictions.

L'invention porte sur des antagonistes de récepteur d'opioïdes kappa qui produisent des améliorations significatives des analyses de liaison fonctionnelle avec des récepteurs d'opioïdes kappa, et sur l'utilisation de ces antagonistes dans le traitement d'états morbides, tels que les addictions à l'héroïne ou à la cocaïne, qui sont améliorés par la liaison du récepteur d'opioïdes kappa.

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