C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/12 (2006.01) A61K 38/17 (2006.01) A61K 39/395 (2006.01) C07K 14/47 (2006.01) C07K 14/705 (2006.01) C07K 16/28 (2006.01) C12N 15/63 (2006.01) C12Q 1/02 (2006.01) G01N 33/68 (2006.01) A61K 48/00 (2006.01)
Patent
CA 2300985
The present invention relates to KCNQ proteins defining potassium channels. In particular, the invention concerns the human KCNQ2, human KCNQ3, murine KCNQ2, and rat KCNQ2 proteins reported herein. KCNQ2 and KCNQ3 proteins are nervous system-selective and may be involved in neurotransmission and neuroprotection. The KCNQ2 and KCNQ3 of the present invention can be used to assay for modulators of the proteins, which would be useful in treatment of such disorders as ataxia, myokymia, seizures, Alzheimer's disease, Parkinson's disease, age-associated memory loss, learning deficiencies, motor neuron diseases, epilepsy, stroke, and the like.
Cette invention, qui a trait à des protéines KCNQ définissant des canaux potassium, concerne notamment les protéines humaines KCNQ2 et KCNQ3, murine KCNQ2 et la protéine KCNQ2 du rat. Les protéines KCNQ2 et KCNQ3 ont une sélectivité pour le système nerveux et peuvent prendre part à la neurotransmission ainsi qu'à la neuro-protection. Il est possible d'utiliser les protéines KCNQ2 et KCNQ3 de l'invention pour des dosages biologiques relatifs à des modulateurs de protéines, pouvant se révéler utiles dans le traitement de troubles tels que l'ataxie, la myokymie, les crises, la maladie d'Alzheimer, la maladie de Parkinson, les pertes de mémoires dues à l'âge, les troubles d'apprentissage, les maladie des motoneurones, l'épilepsie, les accidents cérébrovasculaires et analogue.
Blanar Michael A.
Dworetzky Steven
Gribkoff Valentin K.
Levesque Paul C.
Little Wayne A.
Bristol-Myers Squibb Company
Gowling Lafleur Henderson Llp
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