Keratinocyte derived interferon

Details Keratinocyte derived interferon Keratinocyte derived interferon

C - Chemistry, Metallurgy

12

N

C12N 15/12 (2006.01) A61K 38/17 (2006.01) A61K 38/21 (2006.01) C07K 14/435 (2006.01) C07K 14/555 (2006.01) C12N 15/20 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2335655

The present invention relates to a novel KDI protein which is a member of the interferon family. In particular, isolated nucleic acid molecules are provided encoding a human interferon polypeptide, called "KDI". KDI polypeptides are also provided as are vectors, host cells and recombinant methods for producing the same. The invention further relates to screening methods for identifying agonists and antagonists of KDI activity. Also provided are therapeutic methods for treating immune system-related disorders.

L'invention concerne une nouvelle protéine d'interféron dérivé de kératinocyte, qui fait partie de la famille d'interférons. Elle concerne notamment des molécules d'acides nucléiques isolés qui codent pour un polypeptide d'interféron humain désigné "KDI". Elle concerne également des polypeptides de KDI ainsi que des vecteurs, des cellules hôtes et des procédés de leur fabrication. L'invention concerne également des procédés de criblage visant à identifier les agonistes et les antagonistes de l'activité KDI. Enfin, elle concerne des procédés thérapeutiques permettant de traiter les troubles liés au système immunitaire.

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