C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/12 (2006.01) A61K 38/16 (2006.01) A61K 38/17 (2006.01) A61K 38/18 (2006.01) C07K 14/47 (2006.01) C07K 14/475 (2006.01) C07K 14/50 (2006.01) C12N 5/10 (2006.01) C12N 15/16 (2006.01) C12N 15/63 (2006.01) C12N 15/64 (2006.01) A61K 38/00 (2006.01)
Patent
CA 2399045
This invention relates to newly identified polynucleotides, polypeptides encoded by such polynucleotides, the use of such polynucleotides and polypeptides, as well as the production of such polynucleotides and polypeptides. More particularly, the polypeptide of the present invention is a Keratinocyte Growth Factor, sometimes hereinafter referred to as "KGF-2" also formerly known as Fibroblast Growth Factor 12 (FGF-12). This invention further relates to the therapeutic use of KGF-2 to promote or accelerate wound healing. This invention also relates to novel mutant forms of KGF-2 that show enhanced activity, increased stability, higher yield or better solubility.
L'invention concerne: des polynucléotides nouvellement identifiés, des polypeptides codés par ces derniers; l'utilisation de ces polynucléotides et polypeptides; et leur préparation. En particulier, le polypeptide de l'invention est un facteur de croissance des kératinocytes, parfois désigné sous le nom de <=KGF-2>=, comme c'est ici le cas, ou sous le nom de facteur 12 de croissance des fibroblastes (FGF-12). L'invention concerne également l'utilisation thérapeutique du KGF-2 destiné à favoriser ou à accélérer la cicatrisation, ainsi que des nouvelles formes mutantes du KGF-2, qui présentent une activité améliorée, une stabilité accrue, un meilleur rendement ou une meilleure solubilité.
Coleman Timothy A.
Dillon Patrick J.
Duan D. Roxanne
Gentz Reiner L.
Gruber Joachim R.
Human Genome Sciences Inc.
Mbm Intellectual Property Law Llp
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