Keratinocyte growth factor-2

Details Keratinocyte growth factor-2 Keratinocyte growth factor-2

C - Chemistry, Metallurgy

12

N

C12N 15/18 (2006.01) A61K 31/70 (2006.01) A61K 38/18 (2006.01) A61K 48/00 (2006.01) C07K 14/50 (2006.01) C07K 16/22 (2006.01) C12Q 1/02 (2006.01) C12Q 1/68 (2006.01) G01N 33/53 (2006.01)

Patent

CA 2210444

A human polypeptide and DNA (RNA) encoding such polypeptide and procedure for producing such polypeptide by recombinant techniques is disclosed. Also disclosed are methods for utilizing such polypeptide for stimulating epithelial cell growth which may be used to stimulate wound healing, reduce scarring and prevent hair loss. Antagonists against such polypeptides and their use as a therapeutic to treat proliferative diseases such as cancer, psoriasis, Kaposi's sarcoma, keloids, retinopathy and restenosis are also disclosed. Diagnostic methods for detecting mutations in the KGF-2 coding sequence and alterations in the concentration of KGF-2 protein in a sample derived from a host are also disclosed.

L'invention présente un polypeptide humain et ADN (ARN) le codant ainsi qu'un procédé permettant de le fabriquer au moyen de techniques de recombinaison. Elle présente également des techniques d'utilisation de ce polypeptide aux fins de la stimulation de la croissance de cellules épithéliales pouvant servir à activer la cicatrisation, réduire les cicatrices et empêcher la chute des cheveux. Cette invention présente, de surcroît, des antagonistes de ces polypeptides et leur application thérapeutique dans le cas de maladies prolifératives telles que cancer, psoriasis, maladie de Kaposi, chéloïdes, rétinopathie et resténose. Des méthodes diagnostiques permettant de déceler des mutations dans la séquence codante du facteur KGF-2 ainsi que des modifications dans la concentration de la protéine de celui-ci dans un échantillon issu d'un hôte sont également présentées.

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