Keratinocyte growth factor-2

Details Keratinocyte growth factor-2 Keratinocyte growth factor-2

C - Chemistry, Metallurgy

07

K

C07K 16/22 (2006.01) C07K 14/50 (2006.01) C07K 16/46 (2006.01) C12N 5/00 (2006.01) C12N 5/12 (2006.01)

Patent

CA 2430223

A human polypeptide and DNA (RNA) encoding such polypeptide and procedure for producing such polypeptide by recombinant techniques is disclosed. Also disclosed are methods for utilizing such polypeptide for stimulating epithelial cell growth which may be used to stimulate wound healing, reduce scarring and prevent hair loss. Antagonists against such polypeptides and their use as a therapeutic to treat proliferative diseases such as cancer, psoriasis, Kaposi's sarcoma, keloids, retinopathy and restenosis are also disclosed. Diagnostic methods for detecting mutations in the KGF-2 coding sequence and alterations in the concentration of KGF-2 protein in a sample derived from a host are also disclosed.

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